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This is an example of a typical lifecycle of whole blood processed into serum or DNA and then aliquotted.

In OpenSpecimen, this hierarchical relationship is represented in a parent-child structure. Samples of any lineage can be parents of additional samples. So these relationships do not stop at the aliquot level.

• If a specimen type changes from the parent to the child, then the child sample is ‘Derived’ from the parent.

• If the specimen type does not change, the child specimen is considered an ‘Aliquot’.

For instance, it’s possible to make a primary cultured cell line from a frozen aliquot of PBMCs. This relationship is captured by creating a derivative from an aliquot.

OpenSpecimen uses colored dots as a visual indicator of status to show the status of a sample:

• (green) = sample available

• (red) = sample processed into another product and is no longer available (ie,closed)

• (yellow) = pending

• (grey) = missed or not collected

• (pink) = pooled

• (purple) = reserved

• (blue) = distributed