N3C: Brief Overview
- Amaka Ohiku (Unlicensed)
- Alyssa Hill
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What is N3C?
The N3C is a partnership among the NCATS-supported Clinical and Translational Science Awards (CTSA) Program hubs, the National Center for Data to Health (CD2H) , and NIGMS-supported Institutional Development Award Networks for Clinical and Translational Research (IDeA-CTR), with overall stewardship by NCATS. Collaborators will contribute and use COVID‑19 clinical data to answer critical research questions to address the pandemic.
N3C Data partners
N3C Data partners include:
National Center for Data to Health
The Accrual to Clinical Trials (The ACT Network)
The National Patient-Centered Clinical Research Network (PCORnet®)
Observational Health Data Sciences and Informatics(OHDSI)
TriNetX
N3C Data Enclave
The N3C Data Enclave is a secure platform through which harmonized clinical data provided by our contributing members are stored. The Enclave includes demographic and clinical characteristics of patients who have been tested for or diagnosed with COVID-19 and further information about the strategies and outcomes of treatments for those suspected or confirmed to have the virus. Additional data from individuals infected with pathogens such as SARS 1, MERS, and H1N1 are also included to support comparative studies
This is the first nationwide patient-level dataset in a certified secured environment. EHR data is harmonized into a single model via OMOP, ACT/i2b2, PCORnet, or TriNetX.
CMS Data Linked to N3C Enclave
Center for Medicaid and Medicare(CMS) Data is now linked to the N3C Clinical EHR Data.
Through a generous grant from Assistant Secretary for Planning and Evaluation (ASPE) OS-Patient-Centered Outcomes Research Trust Fund, the National COVID Cohort Collaborative (N3C) is pleased to announce the inclusion of de-identified linked CMS Medicare data to the existing 19 billion rows of mortality, viral variant and clinical data in the Enclave. The addition of CMS is significant to the scientific potential of N3C it will not strengthen the overall capacity of the Enclave but also resolves the issue of missing visits for patients that get their care from multiple providers.
The first batch of CMS data contains over 240 thousand COVID-19 patients and will be updated monthly. The number of CMS patients is dependent on sites participating in the NCATS PPRL linkage initiative, and the number of patients will increase as additional sites implement the tokenization process.
Investigators at the University of Utah registered with N3C will be eligible to submit a Data Use Request project proposal in the Enclave to access the CMS data.
The enclave includes the following data:
• Observations
• Specimens
• Visits
• Procedures
• Drugs
• Devices
• Conditions
• Measurements
• Location
• Provider
Collaborative Research
All researchers looking to interact with N3C data will do so by collaborating with other investigations. Researchers can either start a new project or join an existing one.
Data Level
For Access Requirements for Researchers by Data Level visit
https://ncats.nih.gov/n3c/about/data-overview
How to access N3C
Fill out this Account Request Form
For questions or more information email us at BMIC@ctsi.utah.edu
Additional Information