Introduction

What is TriNetX?

TriNetX is the global health research network that revolutionizes clinical research and enables discoveries by generating real-world evidence. The TriNetX platform provides real-time access to longitudinal clinical data and analytics tools to rapidly answer complex research questions. The TriNetX platform is HIPAA-compliant and GDPR-compliant.

TriNetX has partnered with healthcare organizations (HCOs) spanning 24 countries and thousands of sites, and with data providers covering 99% of US health plans to deploy a linked and continually updated global health research network representing over 300 million patients. TriNetX has been used to analyze over 20,000 protocols and has presented over 5,800 clinical trial opportunities to its HCO members.

Free Access

Researchers at the University of Utah can access the TriNetX Platform, query de-identified data, refine queries, analyze cohorts using built-in analytical tools, determine study feasibility, and download images of their query for IRB submissions and presentations for free.

Where does the data come from?

TriNetX has about 82 healthcare organizations (HCOs) from the United States and other countries that contribute patient data. Electronic health record (EHR) data forms the foundation of TriNetX datasets, but a growing number of additional sources supplement this EHR data.

The HCOs providing this data encompass everything from freestanding acute care hospitals to networks of outpatient clinics.

HCOs contributing to their datasets include:

• More than 100 community hospitals

• More than 500 outpatient clinics

• More than 10 U.S. academic medical centers

• Multiple premier U.S. pediatric hospitals

• A Center for cardiac care and cardiothoracic surgery

What is in the data?

Data from over 73 million patients are available to license and download.
Depending on the length of their record and pattern of care, each patient represents

anywhere from dozens to thousands of “facts”, e.g.

• diagnoses, medication orders, lab results, procedures, or clinical events tied to a specific date

• demographic attributes like race or sex

• genetic variants

• tumor size and staging

Data Format and Structure

A dataset comprises 18 comma-separated value (CSV) files, including a terminology table and manifest table, which you’ll download from the TriNetX platform in a single compressed folder. Each file is a machine- and human-readable data table you can import into your preferred application.

Open

TriNetX data dictionary provides a table-by-table breakdown of the data elements and their type. Please email us at BMIC@ctsi.utah.edufor the complete data dictionary.

Open

How often is the data refreshed?

Each HCO has a Refresh Rate (provided in the HCO Profile) and a data latency. Refresh Rate indicates how often an HCO updates their data in TriNetX, but does not indicate data latency (how recent the clinical information itself is). An HCO refreshing data every two weeks may still be providing the same data set if no new clinical information has been generated at their sites. To view when the data from the HCO was last updated, and how often the data is refreshed by the HCO, go to the Healthcare Organizations analytic and click the Healthcare Organization name to view Last Data Refresh date and Refresh Rate in the HCO profile. Information about Healthcare Organizations is not available on the Research network.

How to get started?

To request access please fill out this form: https://redcap01.brisc.utah.edu/ccts/redcap/surveys/?s=WANY43XHTN

For further information visit:

https://ctsi.utah.edu/cores-and-services/bmic/cohort-query-tools/trinetx

OR email us at:

• BMIC@ctsi.utah.edu